Loaded from the surprise performances at Las Vegas, Britney's second single from Femme Fatale shot to #1, added to her record for having the most #1 song which is her 9th #1. The only act who close to that achievement is Nelly Furtado (7 #1). Where You At? by Jennifer Hudson also bump up after her performance in American Idol 10, while last performer, Black Eyed Peas, debut their song -Just Can't Get Enough- at #6.
| Rank | Status | Single Cover | Description |
| 1 |
|  | Till The World Ends Britney Spears |
| 2 |
|  | On The Floor Jennifer Lopez / Pitbull |
| 3 |
|  | Friday Rebecca Black |
| 4 |
|  | More Usher |
| 5 |
|  | S&M Rihanna |
| 6 |
|  | Just Can't Get Enough Black Eyed Peas |
| 7 |
|  | Loser Like Me Glee |
| 8 |
|  | Born This Way Lady GaGa |
| 9 |
|  | The Show Goes On Lupe Fiasco |
| 10 |
|  | Don't Hold Your Breath Nicole Scherzinger |
| 11 |
|  | Party Rock Anthem LMFAO / Lauren Bennett |
| 12 |
|  | Blow Ke$ha |
| 13 |
|  | Hold It Against Me Britney Spears |
| 14 |
|  | Telling The World Taio Cruz |
| 15 |
|  | Written In The Stars Tinie Tempah / Eric Turners |
| 16 |
|  | Do It Like A Dude Jessie J |
| 17 |
|  | Where You At Jennifer Hudson |
| 18 |
|  | Price Tag Jessie J / B.O.B |
| 19 |
|  | Aftermath Adam Lambert |
| 20 |
|  | I Do Colbie Caillat |
| 21 |
|  | I Need A Doctor Dr Dre / Eminem / Skylar Grey |
| 22 |
|  | Higher Taio Cruz / Kylie Minogue |
| 23 |
|  | E.T Katy Perry / Kanye West |
| 24 |
|  | What Are Words Chris Medina |
| 25 |
|  | All Of The Lights Kanye West / Rihanna / Kid Cudi |
| 26 |
|  | Backseat New Boyz / The Cataracs & Dev |
| 27 |
|  | Bow Chicka Wow Wow Mike Posner / Lil Wayne |
| 28 |
|  | Rolling In The Deep Adele |
| 29 |
|  | 21st Century Girl Willow Smith |
| 30 |
|  | Fuckin Perfect Pink |
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